investigating the effects of low frequency rtms on kindled seizure in rats

نویسندگان

ali yadollahpour ph.d. student in medical physics dept., tarbiat modares university, tehran, iran

seyed mohammd firoozabadi associate professor, medical physics dept., tarbiat modares university, tehran, iran

seyed javad mirnajafi-zadeh associate professor, physiology dept., tarbiat modares university, tehran, iran

چکیده

introduction: neural stimulation is a promising new technology for the treatment of medically-intractable seizures.  transcranial magnetic stimulation (tms) is a simple, non-invasive, low cost technique which is widely used in neurophysiology. in a few studies that have been performed at different frequencies the therapeutic effects of this technique were not obvious. repetition of low frequencies tms (≤1 hz) has inhibitory and quenching effects on neuron activities and it decreases the excitability of the cortex. in epilepsy, as a disease of the central nervous system, the excitability of the cortex increases. it seems that such a technique at its optimum frequencies has therapeutic potential in epilepsy. materials and methods: in this study, the effect of 0.1, 0.5, 1 and 2 hz repetitive transcranial magnetic stimulation (rtms) at an  intensity of  80% resting motor threshold (rmt) and at 1 hz with an  intensity of  90 and 100% rmt  on amygdala-kindling model in rats in optimum spatial coordinate was investigated. the procedure includes delivering a daily 5 minute rtms stimulus using a butterfly figure coil having 25 mm in diameter and the coordinate which induces the maximum electrical field in amygdala area.  the stimulus was given within five minutes after the electrical kindling stimulus was delivered.  the number of days to reach stage 1, 2, 3, 4 and 5 of kindling model after discharge duration (add) in each day and the percentage of cumulative add between the treated and the control group was statistically compared.  two groups were used to investigate the effect of the intensity of the magnetic field. a frequency of 1 hz rtms at an intensity of 90% and 100% rmt was delivered with the same physical parameters as before. results: using a frequency of 1 hz rtms at an intensity of 80% and rmt of 90% showed a significant inhibitory effect on the spread of seizure into other areas of brain in comparison to the control group. increasing the intensity of the magnetic field from 80 to 90% rmt increased the inhibitory effect of this technique.  however, the quenching effect was significantly decreased when the intensity of the magnetic field was increased to 100% rmt. discussion and conclusion:  it seems that the frequency of rtms and motor threshold of subject are important factors in causing physiological effects. this study showed that rtms technique at some frequencies and intensities may have therapeutic effect on epilepsy.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Investigating the Effects of Low Frequency rTMS on Kindled Seizure in Rats

 Introduction: Neural stimulation is a promising new technology for the treatment of medically-intractable seizures.  Transcranial Magnetic Stimulation (TMS) is a simple, non-invasive, low cost technique which is widely used in neurophysiology. In a few studies that have been performed at different frequencies the therapeutic effects of this technique were not obvious. Repetition of low frequen...

متن کامل

study the effects of low level laser diode on no production and healing of diabetic and cortisone acetate and normal wounded sd rats

nitric oxide (no) is a small molecule synthesized by most of mammalian cells with diverse biological activities including vasodilatation, host defense and wound healing. impaired wound healing is a common occurrence among diabetics and patients receiving glucocorticoid therapy. on the other hand the application of laser in biomedical area have been increased. thus, the current studies were desi...

15 صفحه اول

the effects of changing roughness on the flow structure in the bends

flow in natural river bends is a complex and turbulent phenomenon which affects the scour and sedimentations and causes an irregular bed topography on the bed. for the reason, the flow hydralics and the parameters which affect the flow to be studied and understand. in this study the effect of bed and wall roughness using the software fluent discussed in a sharp 90-degree flume bend with 40.3cm ...

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Low-frequency Stimulation Decreases Hyperexcitability through Adenosine A1 Receptors in the Hippocampus of Kindled Rats

Introduction: In this study, the role of A1 adenosine receptors in improving the effect of Low-Frequency Electrical Stimulation (LFS) on seizure-induced hyperexcitability of hippocampal CA1 pyramidal neurons was investigated. Methods: A semi-rapid hippocampal kindling model was used to induce seizures in male Wistar rats. Examination of the electrophysiological properties of CA1 pyramidal neur...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of medical physics

جلد ۴، شماره Issue ۳,۴، صفحات ۷۵-۸۹

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023